10 Best Enzyme Cleaner for Cat Urine 2020 – Reviews & Guide

Last Updated on: October 20, 2020

An enzymatic cleaner for cat urine

We all know how cute and cuddly our little furballs can be to play with, hold, and just watch. That being said, one thing that is not cute is their tendency to urine mark, or have an accident. Urine smells in your home can be overpowering, unsanitary, and very difficult to clean.

It is important to find a good cleaner that is going to be effective, remove odors, and be non-toxic for you and your pet. Though that doesn’t seem like a lot to ask for, it can be an uphill battle trying to find an effective product.

No need to suffer any longer, though. We have found the ten best enzyme cleaners for cat urine available. We will review everything from the effectiveness, odor control, ingredients, work time, and much more. We have also shared some tips, as well, to help you locate the right product.

A Quick Look at our Favorites of 2020:

Image Product Details
Best Overall
Winner
ANGRY ORANGE ANGRY ORANGE
  • Lasts for 80 hours
  • Prevents marking
  • Can be used on all surfaces
  • Best Value
    Second place
    Simple Green Simple Green
  • Spot cleaner
  • Can be used on all surfaces
  • Natural
  • Premium Choice
    Third place
    Rocco & Roxie Supply Co Rocco & Roxie Supply Co
  • Works for hours
  • Chlorine-free and color safe
  • Effective
  • BUBBA'S ROWDY FRIENDS BUBBA'S ROWDY FRIENDS
  • Natural
  • Multi-surface use
  • Effective
  • Sunny & Honey Sunny & Honey
  • Multi-surface
  • Cruelty-free
  • Natural
  • The 10 Best Enzymatic Cleaners for Cat Urine:

    1. Angry Orange Enzyme Urine Cleaner – Best Overall

    ANGRY ORANGE

    Our first choice is the Angry Orange Enzyme Urine Cleaner. This natural bacteria formula will kill odors and stains due to feces, vomit, urine, and any other organic spill that may happen. Available in a 32-fluid ounce bottle, you can use this on rugs, hardwood floors, fabrics, clothes, pet carriers, or any other surface that has a mess. You can also use it to spot clean before washing.

    The Angry Orange is available in a fresh citrus scent or fresh clean scent. Once applied, the enzyme action will last up to 80 hours, plus it prevents your pet from marking. It is 100 percent safe for kids and pets, as well.

    This formula works to convert stains and odors into CO2 and H2O. It works on contact, plus the gentle scent is refreshing and clean. Overall, this is our favorite enzyme cat urine cleaner.

    Pros
    • Effective
    • Lasts for 80 hours
    • Safe
    • Can be used on all surfaces
    • Prevents marking
    • Spot cleaning
    Cons
    • None we can see

    2. Simple Green Cat Stain & Odor Remover – Best Value

    Simple Green

    If you need a more affordable choice, the Simple Green 2010001215311 Cat Stain & Odor Remover is a great alternative to our top pick. It is available in a 1-gallon bottle, 1.25-gallon, or a single 32-ounce option. The formula will permanently eliminate odors and remove stains from almost all surfaces.

    The Simple Green cleaner works on urine, feces, vomit, blood, drool, and any other organic stains that may come your way. It is made with natural enzymes that are non-toxic. It will create safe and clean surfaces and fabrics for your children and pets.

    This is a great cleaner for new or old stains and odors. The only drawback is it doesn’t keep working for quite as long as our first option. That being said, you can use it to spot clean laundry and other fabrics. In general, this is the best enzyme cleaner for cat urine for the money.

    Pros
    • Natural
    • Effective
    • Spot cleaner
    • Safe
    • Can be used on all surfaces
    Cons
    • Doesn’t last as long

    3. Rocco & Roxie Stain & Odor Remover – Premium Choice

    Rocco & Roxie Supply Co

    This next cleaner is the Rocco & Roxie Stain & Odor Remover. This product comes in a 1-gallon or 32-ounce bottle, and it is more expensive than our previous two. You can use this option to remove stains and odors from urine, feces, blood, drool, slobber, and vomit. Any other organic spills can also be dealt with including wine.

    This formula uses natural enzymes to remove odors and stains from your upholstery, rugs, furniture, pet toys, and any other surface that could become stained and dirty. It has a pleasant, light scent, plus it is non-toxic and safe for kids and pets.

    Rocco & Roxie is chlorine and color-safe, so you can use it to spot clean laundry and other fabrics such as curtains, tablecloths, and pet bedding. This formula will also remove any residue left behind, and it continues to keep your home fresh for hours. The only drawback, besides being more expensive, is it does not prevent future marking.

    Pros
    • Affective
    • Can be used on all surfaces
    • Spot clean
    • Works for hours
    • Chlorine-free and color safe
    Cons
    • More expensive
    • Is not preventative

    4. BUBBAS Commercial Enzyme Cleaner

    BUBBA'S ROWDY FRIENDS

    Our next option is the BUBBAS Commercial Enzyme Cleaner. As the name suggests, this is a professional grade formula that will eliminate odors and stains due to any organic spills or “accidents”. It is non-toxic, plus safe for kids and animals once it is dry.

    You can use this cleaner on all kinds of surfaces including rugs, fabrics, hardwood, plastic and much more. The only thing you should be aware of is you want to spot tests on light-colored fabrics to ensure you will not end up with an oil stain.

    Beyond that, the BUBBAS cleaner uses dormant bacteria that becomes active once it reaches that stain or odors. It is all-natural, plus provides a light fragrance that is pleasant. You can also use this product to spot treat clothes before they go in the wash. The only other drawback is this cleaner will not prevent future marking, plus it stops working once it is blotted or washed away.

    Pros
    • Natural
    • Effective
    • Spot cleaning
    • Multi-surface use
    • Safe
    Cons
    • Needs to be spot tested
    • It is not preventative
    • Is not long-lasting

    5. Sunny & Honey Enzyme Cleaner

    Pet Stain & Odor Miracle

    The Sunny & Honey Enzyme Cleaner comes in a 1-gallon or 32-ounce bottle. You can also choose from a fall spice scent or a spring mint scent. This formula is made in the USA, and it is cruelty-free. What’s more, it is natural and safe for your pets and family.

    The Sunny & Honey Enzyme Cleaner can be used on all organic stains such as feces, urine, and blood. The formula will remove odors and stains from most surfaces, although spot testing on fabrics and carpets is recommended especially if they are light-colored. Also, this is not the best option for spot cleaning laundry as it can cause an oil stain to appear.

    Beyond that, this is a great cleaner for ridding your home of nasty smells and stains. It will work to prevent future markings and stains, as well. The only other drawback of note is this product has a very strong scent. Regardless of the particular fragrance, if you do not like spice or mint, it may be too much.

    Pros
    • Natural
    • Effective
    • Multi-surface
    • Cruelty-free
    Cons
    • Spot test on light fabrics
    • Not for spot cleaning
    • Fragrance is strong

    6. Nature’s Miracle P-98150 Stain and Odor Remover

    Nature's Miracle P-98151

    This next cleaner is available in 16, 32, 64, or 128-ounce bottles. The Nature’s Miracle P-98150 Stain and Odor Remover is designed to remove organic spills and accidents from urine, feces, vomit, blood, and slobbery. It will not only neutralize the smell, but it will treat the discoloration, as well.

    Nature’s Miracle is a cat and kid-safe product that uses natural enzymes to clean any nasty spots. You can use this on surfaces such as pet carriers and bedding, carpets, hardwood floors, kitchen counters, and more. Be advised, however, you do not want to use this formula on leather, silk, velvet, satin, or any other delicate items. Beyond that, you should also spot tests on any light-colored rugs or material you need to clean as it can cause discoloration.

    Besides that, this formula has a light scent that is not overwhelming. Unfortunately, it does not prevent any future marking, and it can tackle a consistent amount of product before you notice any reduction of odors.

    Pros
    • Natural
    • Safe
    • Effective at removing stains
    • Multi-surface
    Cons
    • Not recommended on delicate fabrics
    • Spot test
    • Takes longer on odors
    • Is not preventative

    7. TriNova Pet Stain and Odor Remover Eliminator

    TriNova Natural

    The TriNova Pet Stain and Odor Remover Eliminator is a natural and organic formula that is safe and non-toxic. You can use it in spots your pet’s and children play and relax without any harsh chemicals in the air. This formula is used to remove stains and odors from organic pet messiness that can get trapped in your furniture and upholstery.

    One thing of note is this product works better on new stains. Older more stubborn marks and odors will require several treatments before you see a difference. Also, we do not recommend using this product on light or delicate fabrics as they can become stained. Furthermore, you should patch test all material before using this product.

    Available in a 32-ounce bottle, the TriNova has a very strong perfume fragrance that can be difficult for anyone with respiratory issues. What’s more, this option doesn’t have any preventative marking power, and it should not be used as a spot cleaner.

    Pros
    • Natural
    • Safe
    • Good on new stains and odors
    • Multi-surface
    Cons
    • Not effective on older stains and odors
    • Strong fragrance
    • Not for light or delicate fabrics
    • not for spot cleaning
    • Has not preventative maintenance

    8. Simple Solution 11077N-12PONL Enzymatic Cleaner

    Simple Solution

    The Simple Solution 11077N-12PONL Enzymatic Cleaner is available in a 32-ounce or 128-ounce bottle that has a three in one nozzle. You can either use it as a mist, foam, or stream to target stains and odors caused by organic material from your pets. This is a good option for removing urine, feces, and vomit smells and marks. Though this cleaner works better for fresher stains, it can help with older smells.

    The Simple Solution cleaner can be used on plastic, hardwood floors, and carpets or rugs. We don’t recommend you use this on fabrics such as curtains or bedding, and it is not good on clothes. Due to the makeup of the formula, the ingredients can leave an oil stain.

    That being said, this option is safe for your kids and pets. It is made in the USA, but it will not prevent your pet from marking in the future. Also, the fragrance is strong and unpleasant.

    Pros
    • Natural
    • Safe
    • Reduces new stains and odors
    Cons
    • Not for preventive maintenance
    • Strong fragrance
    • Not effective on older stains
    • Can stain fabrics
    • Not recommended for light or delicate fabrics

    9. Urine Gone 20101 Stain & Odor Eliminator

    Urine Gone

    Our ninth pick is the Urine Gone 20101 Stain & Odor Eliminator. This is an enzyme “based” formula that helps eliminate odors and stains. It comes in a 24-ounce bottle, and you can pick it up in a two, three, or four pack. You should note that this formula has a strong chemical smell that can be difficult to take.

    Unfortunately, the Urine Gold is not as effective at eliminating stains and odors as other options. Though it is safe, it can take a lot of applications before you notice a difference, if you see one at all. Furthermore, this cleaner is difficult to use as it requires a decent amount of scrubbing versus the typical spray and blot method.

    Beyond that, you do not want to use this on rugs, fabrics, or textiles. Not only will it stain, but it leaves a strong scent behind on the material. Beyond that, this cleaner does not prevent future marking.

    Pros
    • Natural
    • Safe
    Cons
    • Not as effective
    • Not recommended for light or delicate fabric
    • Strong chemical scent
    • Can stain clothes and fabrics
    • Hard to use

    10. Earth Rated Pet Stain and Odor Remover

    Earth Rated

    Our final option is the Earth Rated Pet Stain and Odor Remover. This is an enzyme cleaner that is meant to remove odors from feces, urine, vomit and other organic spills and mess. Unfortunately, this natural product is not effective. It does not do a credible job at cleaning stains, plus the odor reducing power is non-existent.

    You can pick the Earth Rated cleaner up in a 32-ounce bottle. It also comes in either a lavender or unscented option. Though the unscented has no fragrance, the lavender is more chemical-like, and it can cause respiratory trouble for people or pets who have pre-existing issues.

    Made in the USA, you will not be able to prevent future marking with this product. It can also discolor rugs and flooring, and spot testing on all other materials is highly recommended. Overall, this is our least favorite option for an enzyme cleaner for cat urine.

    Pros
    • Natural
    Cons
    • Strong lavender fragrance
    • Not effective
    • Not recommended on hardwood or rugs
    • Requires spot testing
    • Can stain
    • No preventive maintenance

    Buyer’s Guide

    Shopping Tips

    An enzyme cleaner is a great option for removing nasty pet markings, stains, and odors. Enzymes use natural bacteria to fight organic messes such as urine, feces, and vomit among other things. In fact, this type of cleaner is also used for cleaning drain and sewer pipes, though in a stronger form.

    When choosing one of these cleaners, there are a few important things you want to keep in mind.

    • Effectiveness: An important aspect of an enzyme cleaner is its effectiveness. Not only is the smell of pet waste not appealing, but cat feces in particular can carry diseases that can be detrimental to humans; especially pregnant women.
    • Fragrance: A fresh scent in a cleaner is a great feature as long as it has odor fighting abilities of its own. If you are only masking the scent, it will always return. You want to be able to eliminate it all together.
    • Prevention: Another great benefit of some enzyme cleaners is their ability to prevent future stains and odors. This type of product has an element that will turn your cat away from marking their territory.
    • Surfaces: One of your cat’s favorite places to have an accident is your rug. Many cleaners are approved by the CRI (Carpet and Rug Institute). Though that may seem unimportant, it will assure you that your carpet will not be stained or discolored from the product. Besides that, you always want to spot test light and delicate fabrics to ensure they will not be damaged.
    • Spot Cleaning: Spot cleaning is another important aspect as your pet may find its way to your clothes. Many enzyme cleaners can be used to spot treat fabrics before they are thrown in the washing machine. This will not only help eliminate odors and stains, but it can stop the scent from attaching to other items, as well.
    • Time Frame: Another important note is regarding the time frame of the stains or smells. Unfortunately, you may not notice an issue right away on certain items. This is especially true if your furball can get under the bed, in closets, or elsewhere. A cleaner that will fight older stains and odors can be a beneficial product.

    cat paw dividerConclusion

    We hope you have enjoyed the above reviews. Cat stains and odors can be difficult to deal with especially if you have a kitten or an older cat that has trouble using the cat box. In an effort to keep your home clean and fresh, we hope these reviews have helped you find a product that will work.

    If you want the best of the best, we recommend going with the Angry Orange Enzyme Urine Cleaner. It has powerful stain and odor eliminators, but it is still safe for you family and pets. If you need a more affordable option, the Simple Green 2010001215311 Cat Stain & Odor Remover is a great alternative. It is just as powerful with only slightly less staying power.