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11 Best Cat Urine & Odor Removers 2023 (Enzyme Cleaners) – Reviews & Top Picks

An enzymatic cleaner for cat urine

We all know how cute and cuddly our little furballs can be to play with, hold, and just watch. That being said, one thing that is not cute is their tendency to urine mark or have an accident. Urine smells in your home can be overpowering, unsanitary, and very difficult to clean.

It is important to find a good cleaner that is going to be effective, remove odors, and is non-toxic for you and your pet. Though that doesn’t seem like a lot to ask for, it can be an uphill battle trying to find an effective product.

No need to suffer any longer, though. We have found the 11 best enzyme cleaners for cat urine available. We will review everything from effectiveness, odor control, ingredients, work time, and much more. We have also shared some tips, as well, to help you locate the right product.

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A Quick Look at our Favorites of 2023

Image Product Details
Best Overall
Winner
Hepper Bio-Enzyme Pet Stain & Odor Eliminator Spray Hepper Bio-Enzyme Pet Stain & Odor Eliminator Spray
  • Feature iconNeutral scent
  • Feature iconNo harsh chemicals
  • Feature iconWorks on multiple surface types
  • Best Value
    Second place
    Simple Green Cat Stain & Odor Remover Simple Green Cat Stain & Odor Remover
  • Feature iconSpot cleaner
  • Feature iconCan be used on all surfaces
  • Feature iconNatural
  • Third place
    Rocco & Roxie Pet Stain & Odor Remover Rocco & Roxie Pet Stain & Odor Remover
  • Feature iconWorks for hours
  • Feature iconChlorine-free and color safe
  • Feature iconEffective
  • BUBBAS Cat Urine Enzyme Cleaner BUBBAS Cat Urine Enzyme Cleaner
  • Feature iconNatural
  • Feature iconMulti-surface use
  • Feature iconEffective
  • ANGRY ORANGE Enzyme Pet Urine Cleaner ANGRY ORANGE Enzyme Pet Urine Cleaner
  • Feature iconLasts for 80 hours
  • Feature iconPrevents marking
  • Feature iconCan be used on all surfaces
  • The 11 Best Enzymatic Cleaners for Cat Urine

    1. Hepper Advanced Bio-Enzyme Pet Stain & Odor Eliminator Spray – Best Overall

    Hepper enzyme spray

    There’s no question that the most challenging part of owning a cat is cleaning up after them, especially that strong-smelling urine! If your cat has accidents outside the litter box, you need to find the best way to clean it up. You not only need to remove the smelly odor, but you must also ensure that your cat won’t keep peeing in the same spot.

    Hepper’s Advanced Bio-Enzyme Pet Stain & Odor Eliminator Spray is the best enzyme cleaner for cat urine because it is designed to bind and lift stains and odors on any surface—floors, carpets, furniture, etc. It works well on urine odors and can remove vomit, drool, and feces too.

    It’s eco-friendly and has a neutral scent, so you don’t have to deal with harsh chemical fragrances. Hepper has a 100% satisfaction guarantee, so if you’re not happy with how the spray works, you can get your money back within 30 days of purchase.

    The only flaw with this spray is that it might cause a slight discoloration on the surface that you’re cleaning. This is why it’s essential to test it out on an area that is not noticeable. All in all, we think this is the best cat urine remover of this year.

    At Excited Cats, we’ve admired Hepper for many years and decided to take a controlling ownership interest so that we could benefit from the outstanding designs of this cool cat company!

    Pros
    • Works on floors, carpets, and furniture
    • Binds and removes urine, drool, feces, and vomit stains and odors
    • Eco-friendly and has a neutral scent
    • 100% satisfaction guarantee or money back
    Cons
    • None we can see
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    2. Simple Green Cat Stain & Odor Remover – Best Value

    Simple Green

    If you need a more affordable choice, the Simple Green Cat Stain & Odor Remover is a great alternative to our top pick. It is available in a 1-gallon bottle, 1.25-gallon, or a single 32-ounce option. The formula will permanently eliminate odors and remove stains from almost all surfaces.

    The Simple Green cleaner works on urine, feces, vomit, blood, drool, and any other organic stains that may come your way. It is made with natural enzymes that are non-toxic. It will create safe and clean surfaces and fabrics for your children and pets.

    This is a great cleaner for new or old stains and odors. The only drawback is it doesn’t keep working for quite as long as our first option. That being said, you can use it to spot-clean laundry and other fabrics. In general, this is the best enzyme cleaner for cat urine for the money.

    Pros
    • Natural
    • Effective
    • Spot cleaner
    • Safe
    • Can be used on all surfaces
    Cons
    • Doesn’t last as long
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    3. Rocco & Roxie Pet Stain & Odor Remover

    Rocco & Roxie Supply Co

    This next cleaner is the Rocco & Roxie Stain & Odor Remover. It comes in a 1-gallon or 32-ounce bottle, and it is a pricey product. You can use this option to remove stains and odors from urine, feces, blood, drool, slobber, and vomit. Any other organic spills can also be dealt with, including wine.

    This formula uses natural enzymes to remove odors and stains from your upholstery, rugs, furniture, pet toys, and any other surface that could become stained and dirty. It has a pleasant, light scent, plus it is non-toxic and safe for kids and pets.

    Rocco & Roxie is chlorine and color-safe, so you can use it to spot-clean laundry and other fabrics such as curtains, tablecloths, and pet bedding. This formula will also remove any residue left behind, and it continues to keep your home fresh for hours. The only drawback, besides being more expensive, is it does not prevent future marking.

    Pros
    • Affective
    • Can be used on all surfaces
    • Spot clean
    • Works for hours
    • Chlorine-free and color safe
    Cons
    • Pricey
    • Is not preventative
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    4. BUBBAS Commercial Cat Urine Enzyme Cleaner

    BUBBA'S ROWDY FRIENDS

    Our next option is the BUBBAS Commercial Enzyme Cleaner. As the name suggests, this is a professional-grade formula that will eliminate odors and stains due to any organic spills or “accidents.” It is non-toxic and safe for kids and animals once it is dry.

    You can use this cleaner on all kinds of surfaces, including rugs, fabrics, hardwood, plastic, and more. The only thing you should be aware of is you want to spot tests on light-colored fabrics to ensure you will not end up with an oil stain.

    Beyond that, the BUBBAS cleaner uses dormant bacteria that become active once it reaches that stain or odors. It is all-natural and has a pleasant fragrance. You can also use this product to spot-treat clothes before they go in the wash. The only drawback is that this cleaner will not prevent future marking; it stops working once it is blotted or washed away.

    Pros
    • Natural
    • Effective
    • Spot cleaning
    • Multi-surface use
    • Safe
    Cons
    • Needs to be spot tested
    • It is not preventative
    • Is not long-lasting
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    5. Angry Orange Enzyme Pet Urine Cleaner

    ANGRY ORANGE

    Another great choice is the Angry Orange Enzyme Urine Cleaner. This natural formula will kill odors and stains due to feces, vomit, urine, and any other organic spill that may happen. Available in a 32-fluid-ounce bottle, you can use this on rugs, hardwood floors, fabrics, clothes, pet carriers, or any other surface that has a mess. You can also use it to spot-clean before washing.

    The Angry Orange is available in a fresh citrus scent or a fresh clean scent. Once applied, the enzyme action will last up to 80 hours, plus it prevents your pet from marking. It is 100 percent safe for kids and pets, as well.

    This formula works to convert stains and odors into CO2 and H2O. It works on contact, plus the gentle scent is refreshing and clean. Overall, this is one of our favorite enzyme cat urine cleaners.

    Pros
    • Effective
    • Lasts for 80 hours
    • Safe
    • Can be used on all surfaces
    • Prevents marking
    • Spot cleaning
    Cons
    • None we can see
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    6. Sunny & Honey Cat Urine, Stain & Odor Enzyme Cleaner

    Pet Stain & Odor Miracle

    The Sunny & Honey Enzyme Cleaner comes in a 1-gallon or 32-ounce bottle. You can also choose from a fall spice scent or a spring mint scent. This formula is made in the USA, and it is cruelty-free. What’s more, it is natural and safe for your pets and family.

    The Sunny & Honey Enzyme Cleaner can be used on all organic stains, such as feces, urine, and blood. The formula will remove odors and stains from most surfaces, although spot testing on fabrics and carpets is recommended, especially if they are light-colored. Also, this is not the best option for spot-cleaning laundry as it can cause an oil stain to appear.

    Beyond that, this is a great cleaner for ridding your home of nasty smells and stains. It will work to prevent future markings and stains, as well. The only other drawback of note is this product has a very strong scent. Regardless of the particular fragrance, if you do not like spice or mint, it may be too much.

    Pros
    • Natural
    • Effective
    • Multi-surface
    • Cruelty-free
    Cons
    • Spot test on light fabrics
    • Not for spot cleaning
    • Fragrance is strong
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    7. Nature’s Miracle Pet Stain and Odor Remover

    Nature's Miracle P-98151

    This cleaner is available in 16, 32, 64, or 128-ounce bottles. The Nature’s Miracle Stain and Odor Remover is designed to remove organic spills and accidents from urine, feces, vomit, blood, and slobbery. It will not only neutralize the smell, but it will treat the discoloration, as well.

    Nature’s Miracle is one of the best cat urine neutralizers and is a cat and kid-safe product that uses natural enzymes to clean any nasty spots. You can use this on surfaces such as pet carriers and bedding, carpets, hardwood floors, kitchen counters, and more. It is one of our top picks for the best cat urine remover for carpets, but you do not want to use this formula on leather, silk, velvet, satin, or any other delicate items. Beyond that, you should also spot tests on any light-colored rugs or material you need to clean, as it can cause discoloration.

    Besides that, this formula has a light scent that is not overwhelming. Unfortunately, it does not prevent any future marking, and it can take a significant amount of product before you notice any reduction in odors.

    Pros
    • Natural
    • Safe
    • Effective at removing stains
    • Multi-surface
    Cons
    • Not recommended on delicate fabrics
    • Spot test
    • Takes longer on odors
    • Is not preventative
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    8. TriNova Pet Stain and Odor Remover Eliminator

    TriNova Natural

    The TriNova Pet Stain and Odor Remover Eliminator is a natural and organic formula that is safe and non-toxic. You can use it in spots your pets and children play and relax without any harsh chemicals in the air. This formula is used to remove stains and odors from organic pet messiness that can get trapped in your furniture and upholstery.

    One thing of note is this product works better on new stains. Older, more stubborn marks and odors will require several treatments before you see a difference. Also, we do not recommend using this product on light or delicate fabrics as they can become stained. Furthermore, you should patch-test all material before using this product.

    Available in a 32-ounce bottle, the TriNova has a very strong perfume fragrance that can be difficult for anyone with respiratory issues. Moreover, this option doesn’t have any preventative marking power and should not be used as a spot cleaner.

    Pros
    • Natural
    • Safe
    • Good on new stains and odors
    • Multi-surface
    Cons
    • Not effective on older stains and odors
    • Strong fragrance
    • Not for light or delicate fabrics
    • Not for spot cleaning
    • Not for preventative maintenance
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    9. Simple Solution Cat Urine Enzymatic Cleaner

    Simple Solution

    The Simple Solution Enzymatic Cleaner is available in a 32-ounce or 128-ounce bottle that has a three-in-one nozzle. You can either use it as a mist, foam, or stream to target stains and odors caused by organic material from your pets. This is a good option for removing urine, feces, and vomit smells and marks. Though this cleaner works better for fresher stains, it can help with older smells.

    The Simple Solution cleaner is one of the best enzymatic cat urine removers that can be used on plastic, hardwood floors, carpets, or rugs. We don’t recommend you use this on fabrics such as curtains or bedding, and it is not good on clothes, but it is definitely one of the best carpet cleaners for cat urine out there. Due to the makeup of the formula, the ingredients can leave an oil stain.

    That being said, it is safe for your kids and pets. It is made in the USA, but it will not prevent your pet from marking in the future. Also, the fragrance is strong and unpleasant.

    Pros
    • Natural
    • Safe
    • Reduces new stains and odors
    Cons
    • Not for preventive maintenance
    • Strong fragrance
    • Not effective on older stains
    • Can stain fabrics
    • Not recommended for light or delicate fabrics
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    10. Urine Gone Pet Stain & Odor Eliminator

    Urine Gone

    Our ninth pick is the Urine Gone Stain & Odor Eliminator. This is an enzyme “based” formula that helps eliminate odors and stains. It comes in a 24-ounce bottle, and you can pick it up in a two, three, or four-pack. You should note that this formula has a strong chemical smell that can be difficult to take.

    Unfortunately, Urine Gold is not as effective at eliminating stains and odors as other brands. Though it is safe, it can take a lot of applications before you notice a difference, if you see one at all. Furthermore, this cleaner is difficult to use as it requires a decent amount of scrubbing versus the typical spray and blot method.

    Beyond that, you do not want to use this on rugs, fabrics, or textiles. Not only will it stain, but it will also leave a strong scent behind on the material. Beyond that, this cleaner does not prevent future marking.

    Pros
    • Natural
    • Safe
    Cons
    • Not as effective
    • Not recommended for light or delicate fabric
    • Strong chemical scent
    • Can stain clothes and fabrics
    • Hard to use
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    11. Earth Rated Pet Stain and Odor Remover

    Earth Rated

    Our final option is the Earth Rated Pet Stain and Odor Remover. This is an enzyme cleaner that is meant to remove odors from feces, urine, vomit, and other organic spills and messes. Unfortunately, this natural product is not effective. It does not do a credible job at cleaning stains, plus the odor-reducing power is non-existent.

    You can pick the Earth Rated cleaner up in a 32-ounce bottle. It also comes in either a lavender or unscented option. Though the unscented has no fragrance, the lavender is more chemical-like, and it can cause respiratory trouble for people or pets who have pre-existing issues.

    You will not be able to prevent future marking with this product. It can also discolor rugs and flooring, and spot testing on all other materials is highly recommended. Overall, this is our least favorite option for an enzyme cleaner for cat urine.

    Pros
    • Natural
    Cons
    • Strong lavender fragrance
    • Not effective
    • Not recommended on hardwood or rugs
    • Requires spot testing
    • Can stain
    • No preventive maintenance

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    Buyer’s Guide: Finding the Best Enzyme Cleaners for Cat Urine

    Shopping Tips

    An enzyme cleaner is a great option for removing nasty pet markings, stains, and odors. Enzymes use natural bacteria to fight organic messes such as urine, feces, and vomit, among other things. In fact, this type of cleaner is also used for cleaning drain and sewer pipes, though in a stronger form.

    When choosing one of these cleaners, there are a few important things you want to keep in mind.

    • Effectiveness: An important aspect of an enzyme cleaner is its effectiveness. Not only is the smell of pet waste not appealing, but cat feces, in particular, can carry diseases that can be detrimental to humans, especially pregnant women.
    • Fragrance: A fresh scent in a cleaner is a great feature as long as it has odor-fighting abilities of its own. If you are only masking the scent, it will always return. You want to be able to eliminate it altogether.
    • Prevention: Another great benefit of some enzyme cleaners is their ability to prevent future stains and odors. This type of product has an element that will turn your cat away from marking their territory.
    • Surfaces: One of your cat’s favorite places to have an accident is your rug. Many cleaners are approved by the CRI (Carpet and Rug Institute). Though that may seem unimportant, it will assure you that your carpet will not be stained or discolored from the product. Besides that, you always want to spot-test light and delicate fabrics to ensure they will not be damaged.
    • Spot Cleaning: Spot cleaning is another important aspect as your pet may find its way to your clothes. Many enzyme cleaners can be used to spot-treat fabrics before they are thrown in the washing machine. This will not only help eliminate odors and stains, but it can also stop the scent from attaching to other items.
    • Time Frame: Another important note is regarding the time frame of the stains or smells. Unfortunately, you may not notice an issue right away on certain items. This is especially true if your furball can get under the bed, in closets, or elsewhere. A cleaner that will fight older stains and odors can be a beneficial product.

    cat paw dividerConclusion

    We hope you have enjoyed the above reviews. Cat stains and odors can be difficult to deal with, especially if you have a kitten or an older cat that has trouble using the cat box. In an effort to keep your home clean and fresh, we hope these reviews have helped you find a product that will work.

    To conclude, we think Hepper Advanced Bio-Enzyme Pet Stain & Odor Eliminator Spray is the best cat urine remover on the market. It has powerful stain and odor eliminators, but it is still safe for your family and pets. If you need a more affordable option, the Simple Green Cat Stain & Odor Remover is a great alternative. It is just as powerful with only slightly less staying power.

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